ResearchResearch paperComputer Vision · Interpretability · Robotics & Embodied AI1 source · Oct 13, 2026

Task-evoked eye movements as candidate digital biomarkers of depression severity in adolescents and young adults

Here, we investigated whether task-evoked eye movements provide interpretable behavioral markers of depression severity in adolescents and young adults.

Key points

  • Objective digital measures of depression severity could complement conventional symptom assessments and facilitate more timely clinical evaluation.
  • In this single-center, cross-sectional study, 155 participants aged 14--20 years completed emotional-spatial free-viewing and memory-guided recall tasks and were stratified by 17-item Hamilton Depression Rating Scale scores.
  • We examined 19 prespecified eye-movement features across six task-informed domains using covariate-adjusted ordinal-trend models.
  • Together, these findings identify altered visual exploration and memory-guided gaze control as candidate digital biomarkers of depression severity, rather than generalized negative attentional bias.

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