ResearchResearch paperLarge Language Models1 source · Oct 14, 2026

Amortizing Sequential Experimental Design in Reasoning LLMs

We study how to amortize sequential Bayesian experimental design (BED) into an LLM by explicitly training the reasoning that guides action selection using information-gain rewards.

Key points

  • Despite their extensive pretraining knowledge and strong reasoning capabilities, large language models (LLMs) struggle to adaptively gather information in experimental design tasks.
  • Our approach specifies the experimental generative model independently of the LLM's own beliefs, allowing us to optimize expected information gain under a model of our choosing.
  • We investigate the design choices for amortization, including alternative generative-model constructions, reward estimation, hypothesis-space specification, multi-step objectives, and computational costs relative to training- and inference-time BED baselines.
  • We further demonstrate positive transfer from Twenty Questions training to Medi-Q, a real-world clinical dialogue benchmark.

Sources (1)

  • [1]Amortizing Sequential Experimental Design in Reasoning LLMs
    arXiv (AI, ML, NLP, CV, robotics, multi-agent) · Oct 14, 07:15 PM
    We study how to amortize sequential Bayesian experimental design (BED) into an LLM by explicitly training the reasoning that guides action selection using information-gain rewards.
    Despite their extensive pretraining knowledge and strong reasoning capabilities, large language models (LLMs) struggle to adaptively gather information in experimental design tasks.

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