ResearchResearch paperInterpretability · Computer Vision · Large Language Models1 source · Oct 15, 2026

L2GSSL: Label-Efficient Local-to-Global Self-Supervised Learning for Volumetric Healthcare Data

We present L2GSSL, a local-to-global self-supervised learning framework that leverages unlabeled volumes by decomposing pretraining into intra-slice and inter-slice representation spaces.

Key points

  • Healthcare institutions routinely accumulate high-dimensional computed tomography (CT) volumes, but only a fraction can be annotated by experts.
  • A slice encoder learns view-invariant local features, and a global encoder aggregates the resulting tokens to model volumetric context.
  • On LIDC-IDRI lung nodule malignancy classification, L2GSSL reaches $0.9229$ AUROC with only $10%$ of the labels and $0.9377$ with $25%$, exceeding the volume-level VICReg by $0.0229$ and $0.0294$, respectively.
  • Without adaptation to the external LNDb cohort, a model fine-tuned on $25%$ of LIDC-IDRI obtains $0.8138$ AUROC and $0.7589$ AUPRC, improving over the strongest evaluated self-supervised baseline by $0.1130$ and $0.0954$.

Sources (1)

  • [1]L2GSSL: Label-Efficient Local-to-Global Self-Supervised Learning for Volumetric Healthcare Data
    arXiv (AI, ML, NLP, CV, robotics, multi-agent) · Oct 15, 06:37 AM
    We present L2GSSL, a local-to-global self-supervised learning framework that leverages unlabeled volumes by decomposing pretraining into intra-slice and inter-slice representation spaces.
    Healthcare institutions routinely accumulate high-dimensional computed tomography (CT) volumes, but only a fraction can be annotated by experts.

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