ResearchResearch paperComputer Vision · Interpretability1 source · Oct 21, 2026

LEAF-Mamba: Feature Adaptation and Fusion for Whole Slide Image Analysis

Motivated by these challenges, we introduce LEAF-Mamba, a framework that jointly addresses latent evidence adaptation and fusion for frozen-feature WSI analysis.

Key points

  • Whole slide image (WSI) analysis enables computational diagnosis and prognosis, but gigapixel images and limited annotations make slide-level learning challenging.
  • Multiple instance learning addresses this task by aggregating patch representations from frozen pretrained encoders.
  • Recently, Mamba has enabled efficient modeling of long patch sequences.
  • Parallel Mamba and convolutional streams then capture long-range dependencies and sequence-local interactions, with an input-dependent gate modulating their joint representation before slide-level pooling.

Sources (1)

  • [1]LEAF-Mamba: Feature Adaptation and Fusion for Whole Slide Image Analysis
    arXiv (AI, ML, NLP, CV, robotics, multi-agent) · Oct 21, 01:46 PM
    Motivated by these challenges, we introduce LEAF-Mamba, a framework that jointly addresses latent evidence adaptation and fusion for frozen-feature WSI analysis.
    Whole slide image (WSI) analysis enables computational diagnosis and prognosis, but gigapixel images and limited annotations make slide-level learning challenging.

Extractive summary: sentences quoted from the sources.

Before this

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