ResearchResearch paperLarge Language Models1 source · Oct 19, 2026

CODA: Cohort- and Drift-aware Foundation Model for Multimodal Clinical Reasoning

Motivated by this gap, we propose CODA, a cohort- and drift-aware foundation model for multimodal clinical reasoning.

Key points

  • Recent advances in multimodal foundation models have demonstrated strong performance across diverse clinical tasks.
  • However, existing approaches predominantly operate at the individual sample level and fail to model the interplay between population-level cohort patterns and patient-specific variation that underlie real-world clinical reasoning.
  • CODA explicitly integrates cohort structure into the modeling pipeline through two complementary mechanisms: cohort-aware population stratification and drift-aware individual adaptation.
  • In particular, we leverage reinforcement learning to discover clinically meaningful patient cohorts, and further model each patient's deviation from cohort prototypes as a structured drift signal encoding fine-grained individual heterogeneity.

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